Urinary Metabolites of Dianisidine and Mutagenicity of the Metabolites
نویسندگان
چکیده
منابع مشابه
Relative mutagenicity of some urinary metabolites of the antitumor drug cyclophosphamide.
Four urinary metabolites of the cytostatic drug cyclophosphamide were tested for mutagenicity in the Ames Salmonella assay: nornitrogen mustard (NM), 4-ketocyclophosphamide, 3-(2-chloroethyl)oxazolidone (OZ), and N,N'-bis(2-chloroethyl)piperazine. All four acted as direct base substitution mutagens although 4-ketocyclophosphamide showed an increase in mutagenicity after metabolic activation wit...
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Isoprene, a major commodity chemical used in production of polyisoprene elastomers, has been shown to be carcinogenic in rodents. Similar to findings for the structurally related compound butadiene, mice are more susceptible than rats to isoprene-induced toxicity and carcinogenicity. Although differences in uptake, and disposition of isoprene in rats and mice have been described, its in vivo bi...
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ژورنال
عنوان ژورنال: Sangyo Igaku
سال: 1982
ISSN: 0047-1879,1881-1302
DOI: 10.1539/joh1959.24.7_809_2